Another conundrum

Another conundrum to concentrate on?

IN THE MID-1980S, THE PIONEERING work of Mario R. Capecchi, Sir Martin J. Evans, and Oliver Smithies (jointly awarded The Nobel Prize in Physiology or Medicine 2007) led to the development of gene knockout mice (e.g., Refs. 8 and 13). The use of gene knockout and transgenic mouse models has added essential information to our understanding of renal physiology, including the molecular mechanisms ...

Unruptured brain arteriovenous malformations: another asymptomatic conundrum.

There are 3 major asymptomatic cerebrovascular diseases that challenge the stroke clinician at the bedside. These are asymptomatic carotid disease, unruptured cerebral aneurysms and unruptured brain arteriovenous malformations (AVMs). In all 3 conditions, there are uncertainties about natural history, risks and benefits of intervention. While controversy remains, there have been 2 trials that h...

Thrombosis of an apparently normal thoracic aorta: another case, another conundrum.

We are presenting a new case of thrombosis in the descending thoracic aorta of an apparently normal aorta, which is added to those previously reported.1 The subject is a woman, aged 50 with no previous medical or surgical background of interest. She arrived at the emergency service with a pain on her left costal margin. The chest x-ray revealed pleural effusion. A computerised tomography (CT) w...

Thrombosis of an Apparently Normal Thoracic Aorta: Another Case, Another Conundrum

We are presenting a new case of thrombosis in the descending thoracic aorta of an apparently normal aorta, which is added to those previously reported.1 The subject is a woman, aged 50 with no previous medical or surgical background of interest. She arrived at the emergency service with a pain on her left costal margin. The chest x-ray revealed pleural effusion. A computerised tomography (CT) w...

THE CONUNDRUM OF EUTHANASIA